Effect of xingnaojing injection on myocardial mitochondrial oxidative stress injury in sepsis mice
نویسندگان
چکیده
Objective: To observe the effect of Xingnaojing injection on myocardial mitochondrial oxidative stress injury in sepsis mice. Methods: The septic model were set up by receiving endotoxin by interaperitoneal injection, After consulting Xingnaojing injection by gastric tube, seventy mice were randomly divided into 7 groups, each group of ten. For respective, group LPS-6 h, group LPS-24 h, group LPS-48 h; group XNJ-6 h, group XNJ-24 h, group XNJ-48 h; control group. The myocardial mitochondrial changes, the semi-quantitative scores and the level of SOD, MDA, NO, iNOS in sepsis mice were observed. Results: Xingnaojing injection could improve the myocardial mitochondrial changes and reduce the semi-quantitative scores, significantly reduce the level of MDA, NO, iNOS and elevate the level of SOD. Conclusions Xingnaojing injection could significantly reduce the myocardial mitochondrial oxidative stress level and improve the ability of clearing oxygen radicals, thereby protect the myocardial mitochondrion in
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